Who Should Not Use These Medications?
While GLP-1 and dual-agonist medications are effective for many people seeking weight loss support, they are not appropriate for everyone. Understanding who should not use these medications is crucial for ensuring safe and effective treatment. An independent licensed provider will conduct a thorough medical evaluation to determine whether these medications are suitable for an individual health situation.
Contraindications and Safety Concerns
Certain medical conditions make GLP-1 and dual-agonist medications unsafe or inappropriate. An independent licensed provider will screen for these contraindications during your initial consultation. Common reasons someone might not be eligible include personal or family history of medullary thyroid carcinoma (MTC), a type of thyroid cancer. Additionally, those with a history of multiple endocrine neoplasia syndrome type 2 (MEN 2) should not use these medications.
Pregnant women and those planning pregnancy should not use these medications, as safety in pregnancy has not been established. If you become pregnant while taking these medications, discontinuation is recommended, and you should notify an independent licensed provider immediately. Breastfeeding while on these medications is also not recommended without provider guidance.
Severe Kidney or Liver Disease
Those with severe kidney disease may require dosing adjustments or may not be appropriate candidates for these medications. While GLP-1 and dual-agonist medications are not contraindicated in mild to moderate kidney disease, more severe impairment requires careful evaluation. Similarly, those with significant liver disease should discuss their eligibility with their provider, as dose adjustments may be necessary.
Diabetic Retinopathy Considerations
Patients with severe diabetic retinopathy (eye damage from diabetes) require special consideration. While GLP-1 medications can be used in some patients with this condition, rapid weight loss may rarely lead to worsening of retinopathy in those with existing severe disease. An independent licensed provider will assess this carefully during your evaluation.
History of Pancreatitis
Those with a personal history of acute pancreatitis or those at high risk for pancreatitis should use these medications with caution. While pancreatitis is rare with GLP-1 and dual-agonist use, an independent licensed provider will evaluate your individual risk factors. Any signs of pancreatitis—such as severe abdominal pain—should be reported to your healthcare provider immediately.
Allergies or Sensitivities
If you have known allergies to any components of the medication you’re being considered for, you should not use that medication. Let an independent licensed provider know about all drug allergies and sensitivities during your consultation. There are multiple medication options available, so alternatives may be considered if needed.
Certain Medications and Interactions
GLP-1 and dual-agonist medications may interact with certain other drugs, particularly diabetes medications. If you’re taking insulin or certain diabetes pills, dosage adjustments may be necessary to prevent low blood sugar. An independent licensed provider will review all your current medications and assess potential interactions.
Dehydration and Gastrointestinal Issues
Patients with conditions causing severe dehydration or those with a history of gastroparesis (delayed stomach emptying) require careful evaluation. These medications slow gastric emptying naturally, which could worsen existing gastroparesis symptoms. Staying well-hydrated is important when taking these medications, so those unable to maintain adequate hydration may not be good candidates.
A Comprehensive Evaluation
Safety comes first. During an initial consultation, an independent licensed provider will conduct a comprehensive evaluation including a detailed medical history, physical exam, and lab work to determine whether someone is a good candidate for treatment. If you have concerns about your eligibility, you can discuss them directly with the provider.
For more information about eligibility requirements, find an independent licensed provider. You can also review our frequently asked questions or explore our medication guides to learn more about the evaluation process. Additional educational information is available in our documentation.
Disclaimer: Results vary. Eligibility determined by a licensed provider. These medications have specific contraindications and are not appropriate for everyone. Always disclose your complete medical history to an independent licensed provider.