MOTS-c Research Document (40mg)

MOTS-c Research Document (40mg)

Neutral technical overview for laboratories and qualified professionals.
This page focuses on documentation, storage, handling, and research context.

MOTS-c is a mitochondrial-derived peptide investigated for its role in metabolic homeostasis, stress responses, and exercise-mimetic signaling in preclinical studies.

For Research Use Only. Not for human or animal consumption, medical treatment, or diagnostic use.
Content is informational and must not be used as dosing, clinical, or therapeutic guidance.

At a Glance

Document Purpose

  • Summarize recommended lab-focused storage and handling concepts.
  • Support internal SOPs, audit trails, and chain-of-custody records.
  • Provide a consistent structure across GLP3 research documentation.

Key Topics & Use-Cases

  • Mitochondrial-encoded peptide biology
  • AMPK activation and metabolic reprogramming
  • Peptide stability and light/temperature sensitivity

Common Research Contexts

  • Cell models of insulin resistance and oxidative stress
  • Exercise, aging, and mitochondrial signaling studies
  • Multi-omics profiling of MOTS-c exposure

Storage & Stability Considerations

  • Store sealed vials in accordance with supplier guidance (e.g. frozen or refrigerated) and protected from light.
  • Log receipt date, lot/batch, and initial storage conditions at intake.
  • Minimize repeated freeze–thaw cycles; prepare aliquots at first use when appropriate.
  • Label aliquots with lot, aliquot date, and intended expiry per internal SOP.
  • Use dedicated, validated temperature monitoring where required for QA/QC programs.

Handling, Reconstitution & Aliquoting

  • Conduct all manipulations in a clean environment using appropriate PPE (gloves, coat, eye protection).
  • Use sterile, nuclease-free diluents and consumables when sterility or assay sensitivity requires it.
  • Document reconstitution protocol: diluent identity, target concentration, and final volume.
  • Gently mix to avoid foaming or shear stress; avoid incompatible solvents or extreme pH unless validated.
  • Dispose of unused material and consumables via institutional chemical/biological waste procedures.

Minimum Documentation Checklist

To support traceability and regulatory-aligned lab practice, maintain:

  • Supplier documentation: Certificate of Analysis (COA), specification sheet, and safety information.
  • Lot-level records: batch/lot ID, quantity received, and responsible personnel.
  • Storage log: conditions, equipment IDs, alarms/incidents, corrective actions if applicable.
  • Aliquot map: locations, labels, concentrations, and dates of preparation.
  • Use log: experiment IDs, dates, operators, and reference to raw data and protocols.
  • Periodic review of stock integrity (visual check, where appropriate analytical confirmation).

Example Non-Clinical Research Models

The compound described on this page is used strictly in controlled non-clinical settings.
No human dosing guidance or off-label promotional content is provided or implied.

  • In vitro assays (e.g. receptor binding, signaling cascades, gene/protein expression).
  • Mechanistic models exploring pathways such as metabolism, inflammation, regeneration, or neurobiology.
  • Analytical method validation where the peptide is used as a reference or system suitability standard.
  • Other ethically approved models consistent with institutional, national, and international regulations.

Compliance & Risk Management Notes

  • Classify and handle as a research chemical according to institutional risk assessments.
  • Restrict access to trained personnel; maintain documented training where required.
  • Verify that procurement, storage, and use comply with local laws and professional guidelines.
  • Do not advertise or position this material as a finished drug, supplement, or cosmetic ingredient.

References & Evidence Snapshot

This summary is informed by publicly available scientific literature, supplier technical data,
and standard peptide handling practices. Users should consult primary peer-reviewed sources,
regulatory documents, and internal SOPs before designing or interpreting any study.
No efficacy or safety claims for human use are made or endorsed.